If it is a purpose made motorhome tank then it should be sealed apart from the overflow (assuming that the filler and any inspection cover is properly tightened).
What you can do is to modify the overflow pipework. You would need to fit a short vertical section of pipe from the tank outlet and connect that with flexi pipe (or rigid plastic if you wish) to the existing.
If your overflow comes out of the top of the tank and you are short of height, then fabricate a large U bend into the system. The only downside to that would be draining it in Winter.
Basically, you are stopping a free flow by putting an obstruction of sorts into the line. If you were to overfill your tank by mistake, the excess water would still run out as it is still an open ended pipe.
I tend to travel with the minimum of water but I check in advance for places I can fill up just before (or at) my destination.